Like ShoGofast said, you will still want to be cautious about turning the boost up but overall the tune should adapt itself fine.
Just for your edification: 3.5psi boost in the wastegate on my old 3L with intercooler yielded:
246/220 wHP/TQ and this is with the same high-boost tune; i.e. retarded ignition timing.
The boost was so low the intercooler probably did next to nothing since it was a water-to-air and could potentially have warmed the air somewhat over ambient at low pressures.
With a 3L non-intercooled on 4psi you can probably expect about the same, 250wHP and even more torque than I had.
You almost don't need much timing retard at all on 4psi or less boost with high octane fuel.
So yes, I'm saying with a 3.5psi spring and high octane, fuel you could probably run with a stock tune and make really good power, especially since stock tunes run notoriously rich. This goes for the standard 2.5L engines as well but obviously they'd be running in the low 200's wHP range.