I enjoyed driving to Bakersfield from LA early in the morning. Really pretty sunrise.
I also like driving from the San Fernando Valley (i.e. Woodland Hills) and taking the street to Culver City (where I used to live). Particularly at sunset.
Driving to Ventura County (NAWS Point Mugu) from Woodland Hills is also kinda cool, but it's REALLY LONG.
I also love PCH.
Long Beach is pretty at all hours, especially sunset.
From LA to Fontana early in the morning is also cool.
Palmdale is also nice. I have a few pics, actually. Have to post them.