occasionally when I'm running it; no mod's except for door speakers and it happens whether cd or radio is in use. If this is already addressed please point me to the post. Otherwise, it stays on when it happens but the volume drops and any configured settings change to factory(?) default.

Sounds like the HU is bad.

Since I posted I've been paying closer attention to how it occurs and if I'm near top volume it happens relatively quickly; today I ran it @ 3/4 volume for 2 hours and it didn't happen at all. I'm thinking (and hopeful) that I had been over working the amp since I intend to replace that. Thanks for your input.

Yeah, didn't think about that...

Could also be the amp going bad!