Absolutely. Certain carriers run specials if you fly out on Saturdays; others seem to like Tuesdays and Wednesdays for one reason or another. Play with the dates a bit and see what you can come up with. I've shaved a little bit off of ticket prices by flying early in the morning, late at night and on certain days.
You most likely won't save hundreds off of the ticket, but if you are watching your dollars and are flexible you can save $50-75...
