I stopped paying attention to the gauge a while ago. I go strictly by mileage.
For example, I average around 23-24 mpg. So I figure that even with horrible mileage, say, 20 mpg, I'm going to get at least 280 miles out of a tank. So I reset my trip counter each time I get gas, and when it gets to around 240-260 miles _ regardless of what the gauge says _ I fill up again. Sure, there's usually something left in the tank, but I've been told time and time again it's not healthy to let a car's tank get all the way to "E" all the time. And over a long enough time line, you're shelling out the same amount of $ for gas.