Actually running the larger injectors is not a good idea. You come up with a lot of drivability problems and bad efficiency since the majority of the time they are running at very sub par duty cycle.
Chris is running 30lb injectors and Tom is running 36lb injectors respectively. Their power numbers are well known. The injectors are not tasked in either case (especially Tom's)
Now running 42lb injectors to make much less peak HP (and peaky it will be with their stated turbo but that's another story) is serious overkill 90% of the time!
The ignorant crack about ease of tuning to run smaller injectors really shows the lack of knowledge on their part. The smaller injectors were picked for a specific reason. They supplied more than enough fuel (as well dyno proven and tested) and give great drivability and efficiency the other majority of the time you are not in heavy boost.
Tuning the A/F is tuning the A/F regardless of injector sizing. Intentionally picking oversized injectors for the application is what shows lack of tuning/design ability.
As for the fuel pump remark.
The stock return style pump can support around 240-250FWHP. Yes upgrading is probably a good idea.
The stock returnless pump can support at least 300 FWHP (the 19lb injectors can not, but we've previously touched on that)
However the pickup screens are suspect. Yes upgrading is probably a good idea, but shown not to be necessary.
However NOT with an inline pump.
Upgrading the in-tank pump is the correct way to go about this. It's also the only option you want to use for a returnless application since the PCM controls the in-tank pump via voltage!