On Tom's 3L 24lb injectors at ~200FWHP are at 60% duty cycle (real info, not any formulas here)
That's a lot of duty cycle left to accommodate the nitrous.
So even a hot 3L at 230FWHP still would have ~20% DC left. (using a 95% max)
24lb injectors can safely support around 290FWHP and max at 325FWHP
If you were truly planning to run a lot of Nitrous (100+) 30lb injectors may be a better choice for a returnless car.
Now a return style car can get away with using smaller injectors and raising the fuel rail pressure. Definitely not the best way to do things but it would work. Plus since you are not using the nitrous very often the fuel fual rail pressure would not be a constant. (I.E. like an FI'd car with an FMU)
For Ref - We know that on the returnless cars the stock 19lb injectors will safely support 225 FWHP and as much as 250-255FWHP. (Chris's testing and a couple Venom kits that maxed the injectors - very lean!

)
I still don't see why you are claiming 100 octane is what you would have to run. YOU CAN TUNE the engine to run on any octane. This is where the dyno tuning comes in.
I do agree more octane is better since it will let you make more power.
With that said it is not hard to add 1 gallon a Xylene to a partial tank to raise your octane.
1 gallon of Xylene in 4 gallons (quarter tank) of 92/93 equals 98-99 octane fuel.
1 gallon of Xylene in 7 gallons (half tank) of 92/93 equals 96-97 octane fuel.
1 gallon of xylene in a full tank raises it 1.5-2 octane. (not points like the POS boosters do!)
That's something you can do anytime and not have to find a "special gas station"
I think it's a given that you would need some dyno tuning to run Nitrous on a hybrid. Heck if it were me I would dyno tune ANY nitrous setup on any car. What's $100 compared to a new engine!
At that rate I would dyno tune any hybrid in the first place since it's well out of the normal parameters of the stock PCM program.
It's actually quite a statement the Ford EEC-V can adapt to the changes made. (It is quite an in-depth system & code)
Heck Brad even runs/ran Silvie on about every grade of octane out there without any problems.
IMO any problems with a 3L hybrid are in the re-building. (flame suit on!) The 2 that have been around the longest have been beat on and abused the most and are still going strong! Brad's didn't even get a full rebuild!