I've got a true dual 2 1/4" system, but am going to a single 3" next week. I also have a set of gutted manifolds, but haven't installed them yet.
I am using an Aquamist system, I just posted a few pics of it in the pics and videos section. Am intercooler would be your best bet, but space is a serious issue with that, it could be done though.
300+whp is a real possibility with the vortech. I am probably putting out close to 285 now due to mods I've done since my last dyno. After a custom chip and bigger injectors, I hope to top 300.
