One question: What are you going to use to control the bigger injectors and properly attain an air/fuel ratio that will produce max power? I only ask because I have seen Cardoc say he doesn't like the S-AFC. I can guarantee that the stock PCM won't do it and will throw rich CELs within a few days. Been there, done that.
Custom chip is the best way to go IMHO. "Ford 80 mm MAF calibrated for 24# injectors" is not a valid answer.