OBD-II will not make any adjustments to "tune" this mod out just as any other computer system... I have done this before on OBD-II cars with NO problem and the same exact effects as other cars.
Again, it WILL affect WOT setting to some degree because there are only a few sensors that WOT goes off of for any adjustment, and the TPS is one of them. In WOT, both up-stream and down-stream sensors are completely disregarded as are the EGR system and other emissions system components. Considering WOT begins at a certain percentage of TPS voltage, your car will go into WOT a little bit sooner on the gas pedal depress as well as have a slightly higher voltage when opened all of the way therefore slightly altering the fuel curve table. You are not going to see any difference in gas milage either, you won't kill your milage, trust me, your just improving the throttle response, that's it, but there are a lot of people out there that find it very worth it.
I am not trying to argue here, this is what has been proven before on other cars... like I said, you are not getting 10 more HP or anything, you are getting a MUCH better throttle response throughout the RPMs as well has how much gas you give it and your car will pull sliiiightly harder when you nail it.