if you have no concern for multimedia or gaming nt 4.0 isn't a bad choice. Although it's terrible for games and multimedia in general.
I haven't made the move to XP yet, I'm still running 2000 pro, I can usually get 2 weeks out of uptime so that is good enough for me. With NT4 I had about 6 weeks without a restart, using the computer everyday.
Do you own this software or are you going to buy it? :p
HTH,
Pete