No matter what caliber (.357, .44, or .50), the standard Desert Eagle is just too large and bulky to be a "working gun"; now the Jericho that was subsequently branded and resold by Desert Eagle looks to be a more promising candidate, but this is honestly the first time I've ever heard of one.
That doesn't mean squat, since most of the folks I shoot around with are Colt, Sig, Glock, Wilson Combat, Beretta, HK or Kimber fools. I see the occasional Ruger and Smith, but I rarely see or shoot many other pistols outside of the ones I've mentioned. Every now and then someone shows up with a wacky wheel gun (ever heard of a .454 Casull?) or wild-ass auto (.357 Coonan?), but it's few and far between...
Anything that can handle a .44 or .50 round and has a clip on it is a glorified carbine that needs a rifle butt stuck on the end of it and a longer barrel.