Just checked the address, and that hotel is twelve blocks south of the Pavilion. I'm trying to think back on the two times that I went there last year, and where the sketch-border is. I think that you're near it, unless you like seeing all sorts of curse-laden pot-leafed t-shirts in the store windows all of the time. But the Pavilion also has an old rollercoaster, and there's a Ripley's Believe It or Not museum there.
I'd think maybe about moving four blocks further south unless the sounds of 18 year olds getting rowdy and puking make you sleep better. I personally like having a buffer in there where people would be too lazy to walk around at 4 am and mess up your stuff. Then again, Horry County's finest are pretty good at shaking up the buttsticks.
Must-sees include the NASCAR Cafe and doing some karting there; the food's good but at a nine dollar burger, it's pricey for what it is. That's near Boulevard at the Beach which has a bunch of cool restaurants, clubs and shops in it.
If you're into outlet shopping, there is a huge outlet just outside of South Myrtle heading inland.
North Myrtle Beach (a separate town) has more shows and ginormous Calabash (read: fried) buffets and there's a House of Blues up there too. That's about a twenty minute drive from the Pavilion area.
Golf? If so, there is no other place on the East Coast that has as many courses. Not to mention the eleventy jillion Putt-Putt courses that try to outdo each other.
From anywhere on S. Ocean Blvd you can walk three blocks inland and find ice cream joints, breakfast places, and good eats. Don't worry about bringing chairs and stuff all the way from where you are, there are places like Wings, Eagles and so forth where you can buy an eight dollar chair to sit in the surf with and just pitch it when you're done. Same with $0.99 beach towels, five dollar flipflops, suntan lotion and the like. The wifey'll probably want to bring her suit though. Those shops are everywhere, so don't bother stopping on the way down at those further away.
