2nd Administration shakeups are nothing new. Look at Clinton and Regean administrations for examples...
I'd hate to see Rice leave, Ashcroft hasn't been a great boon or burden and I'd DREAD seeing Powell leave.
Rumsfeld? I'd cheer him out the door.
Honestly, I don't see how any of them have any hair remaining on their heads or not two steps away from a padded cell, as the strain has been simply astonishing since 9/11. I bet stress is the #1 factor in making the departure decision for many of these people...
It should be good to see some fresh blood in this administration. There are certain characters that I sincerely hope will stay the course, though.