I've heard of a few folks running slicks.
PhatSVT (S/C SVT) has slicks already and is getting a Terry Haines prepped MTX-75 (quaife, gears, clutch, etc)and he'll be running them next spring!!!
Do I hear a HELL YEAH!!!
Haven't heard of anyone building up the bottom end. IIRC someone was trying the SHO bearings (from SHO V8) & a few people have sources for Forged & even titanium parts (rods, crank, pistons)