I'm adding an Infinity Reference 7540A 4 ch. amp and new Infinity Kappa 5X7's. Just a couple of questions:

Will upgrading to 16 ga wire instead of factory wiring make a noticeable difference in SQ?

If so, what's the best way to get from the interior of the car into the doors with new speaker wire? Any other way to do it than drilling into the door near the factory wiring harness and drilling into the car nearby? Recommendations for protecting speaker wire from damage? Any past experience here?