I know lots of people that have dumped TT setups for a single turbo.
Several Supras come to mind first. They are always a ton faster... Imagine that.. Better efficiency = better power; every time...
I ran a 20G turbo on my Conquest (among others - 12A, 14G, 16G, T3/4) and never had boost lag problems. The only time it showed lag was below 2900rpm. I don't even cruise below 3k...

Exhaust setup can greatly reduce lag by itself (as shown by my Conquest's 3" single piping) and the newer turbos with VVT are even better!