283 should drop you off on rt30 in York. From York to Lancaster (Amish Shops Everywhere) it is a small highway. From Lancaster to Coatesville it is backroad which isn't too bad. 30 then splits... local will take you right through coatesville or you can take bypass 30 to rt82 exit. Don't backtrack from 100.
Overall I don't think its much more then an hour from 283 to coatesville.