Overall their bread & butter cars (Civic, Accord) are boring and somewhat overpriced. I was definitely not impressed with any aspect of the last Civic I drove ('03 Coupe EX 5 Spd.). I haven't had the opportunity to drive an S2000, but I'd probably like it.
Acuras are a somewhat different story - I drove a CL Type S that was pretty sweet. But I personally wouldn't pay that much for a FWD car. I've ridden in my friend's TSX and it didn't do much for me.
A lot is said about their reliability and build quality, but I've seen plenty of Civics and Accords that are about 5 years old and have as many problems (squeaks, rattles, minor defects) as any other car.