That's the beauty of the AFC - you can get it set, make a mod (especially a BIG one like headers), and then adust it. However, you NEED to dyno tune it to get it optimized. I'm running on street tune and I know I don't have it perfect.
Even trying to match the O2 readings recorded from my last dyno tune ended up being too rich. Last time I dyno tuned, 0.94 V at the O2's was 12.5:1. Last time I street tuned to 0.94 V I ended up fouling the hell out of my plugs by running too rich. I ended up setting the O2's to 0.90 - 0.91 volts that night. Hopefully I can get a little cheap dyno time at SZ after the organized runs.